From the Super Mario Wiki, the Mario encyclopedia
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SPD-Up is a positive status effect experienced in Mario & Luigi: Superstar Saga, Mario & Luigi: Partners in Time, Mario & Luigi: Bowser's Inside Story and Mario & Luigi: Paper Jam. It stands for "Speed-Up". In Partners in Time, by ingesting a Blue Pepper, Mario and Luigi can increase their Speed, allowing them to attack before their enemies. The effect is indicated by an expanding blue circle of aura around Mario or Luigi. In Paper Jam, Bowser and Paper Mario can get this status condition, getting it along with the bros using a SPD-Up Battle Card. In all other games, only enemies can power themselves up with this condition. Rising blue streaks signal the power-up.