From the Super Mario Wiki, the Mario encyclopedia
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Sick is a status ailment in Mario & Luigi: Bowser's Inside Story and its 3DS remake, Mario & Luigi: Bowser's Inside Story + Bowser Jr.'s Journey. Certain enemy attacks, especially those from Blizzard Midbus, sleeping Naplocks, and Sniffle Thwomps can cause Bowser to become Sick if they hit. When sick, Bowser glows blue around him and has a runny nose. Every turn, Bowser sneezes and lose a chunk of HP, ranging from either 15, 30, 60, 75, 90 or even 120 HP. It is much like the poison status effect that Mario and Luigi can be inflicted with, although Bowser is the only one who can get the Sick status and he cannot be poisoned in the traditional sense.