From the Super Mario Wiki
Anne Hathaway was the wife of William Shakespeare. They married sometime in 1582, and stayed married until Shakespeare's death in 1623. During their time together, they had three children: Susanna Hall, Judith Quiney, and Hamnet Shakespeare. In Mario's Time Machine, she meets Mario after he travels back in time to Stratford-upon-Avon in 1601 to return Shakespeare's Skull.
Mario's Time Machine
According to Mario's Time Machine, Anne Hathaway lived in Stratford-upon-Avon in 1601. Mario visits her in her home and, after he says that he is looking for William Shakespeare, she introduces herself as her husband and then says that he is at the theater. Mario assumes that he is there to watch something, but Anne clarifies that the theater is staging his play. Mario then asks if Shakespeare has lived in Stratford his entire life, and Anne responds to the positive. She also talks about her three children, including Hamnet, who unfortunately passed away. She says that he is "with the angels, yet how far that little candle still throws his beams," which is an indirect quote from The Merchant of Venice where Portia sadly talks about how a tiny candle seems so bright in a room full of darkness, metaphorically referring to how a single good deed stands out in a place full of wrongdoers. Mario notices that she quoted one of Shakespeare's writings, and goes on to talk about the various topics that her husband covers in his writings, but suddenly remembers that she is missing the kitchen knife that she needs to prepare a turkey. Once Mario retrieves the Knife from Richard Burbage and brings it back to her, he mentions that Richard needed a feather to complete his costume. Anne promptly gives him the Feather in her possession, which has apparently been used in many plays. Mario then wonders out loud if the Skull in his possession is also a part of a play, and Anne tells him that it is most likely a part of Shakespeare's newest play, Hamlet. She then tells him to return it to Shakespeare immediately.