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A capsule like object with two colors; either the same or different.

First appearance

Dr. Mario (1990)

Latest appearance

Super Smash Bros. Ultimate (2018)

Effect on player

Defeats a virus of the same color when four are piled up.
Dr. Mario juggling three Megavitamins

Megavitamins are Dr. Mario's prescription of choice, seen in the Dr. Mario series. Invented by Dr. Mario himself[1], Megavitamins are an effective weapon against both viruses and the flu[2].

They come in six different color combinations of red, blue, or yellow (Red+red, blue+blue, yellow+yellow, red+blue, yellow+blue, red+yellow, or in the Game Boy version Black+black, grey+grey, white+white, black+grey, black+white, and white+grey). Dr. Mario uses the Megavitamins to destroy viruses, in the game Dr. Mario. In Japanese, Megavitamins are simply called カプセル(Kapuseru); Capsules[citation needed].

In Super Smash Bros. Melee, Super Smash Bros. for Nintendo 3DS / Wii U, and Super Smash Bros. Ultimate, Dr. Mario's standard special is Megavitamins, in which Dr. Mario tosses a Megavitamin at opponents. They act the same as Mario's Fireball move, except that the Megavitamins are more powerful. They also bounce in a different path, and make a different noise when it hits. There's also a trophy of Dr. Mario shooting Megavitamins and one of the vitamins themselves. Kirby is also able to use the Megavitamins if he copies Dr. Mario, although the sound that plays when the Megavitamin hits an opponent is different. Like in the Dr. Mario games, the Megavitamins are randomly generated with different color combinations, though this has no effect on the attack itself. Super Smash Bros. for Nintendo 3DS / Wii U also gives this move two customizable variants, which are similar in effect to Mario's Fireball customs. The first is Fast Capsule, which sends out a fast-moving but weaker Megavitamin that travels directly forward, and the second is Mega Capsule, which sends out a slow-moving giant Megavitamin that does not travel as far but deals multiple hits of damage.

In Super Smash Bros. Brawl, a Megavitamin appears as a Sticker, which boosts the attack of the equipped character by five points.

In Dr. Mario 64, Megavitamins also seem to have a transforming property; when Dr. Mario or Wario eats them, they transform into Metal Mario and Vampire Wario, respectively.

In WarioWare, Inc.: Mega Microgame$!, a minigame called Dr. Wario features Wario in a doctor persona using megavitamins to eliminate viruses. In addition, starting with the game Dr. Luigi, Luigi's doctor persona also uses megavitamins to eliminate viruses. Also starting with Dr. Luigi, L-shaped megavitamins have been used.


Trophy information[edit]

Name Image Game Description
Megavitamins Trophy155.PNG Dr. Mario
Megavitamins come in six color combinations of red, blue, and yellow. Dr. Mario uses these capsules by tossing them into contaminated bottle to destroy viruses. The origin of these wonder pills is a mystery, but the most likely theory is that they're the result of Dr. Mario's lifelong efforts to find a cure for the common cold.



  1. ^ "I have just developed a new vitamin that should be able to take care of it. I sure hope this stuff works!" Dr. Mario instruction manual for NES, page 3.
  2. ^ "Flu season has struck! Now Dr. Mario, armed with his mighty Megavitamins, is busier than ever treating patients." Dr. Mario 64 manual, page 13.