Dr. Mario Online Rx

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"Virus Buster" redirects here. For information about the microgame from WarioWare: Get It Together!, see Virus Buster (microgame).
Dr. Mario Online Rx
Dr. mario online rx.jpg
Developer Arika
Nintendo SPD Group No. 2
Publisher Nintendo
Platforms Wii
Release date Japan March 25, 2008
Europe May 20, 2008
Australia May 20, 2008
USA May 26, 2008
Genre Puzzle
ESRB:ESRB E.svg - Everyone
PEGI:PEGI 3.svg - Three years and older
CERO:CERO rating A - All ages
ACB:ACB G.svg - General
Mode(s) Single-player, 1-4 players simultaneous, multiplayer online
Digital download icon for use in templates. Digital download

Dr. Mario Online Rx (stylized as DR.MARIO online ℞ on the logo), known as Dr. Mario & Germ Buster in Europe and Australia and as Dr. Mario & Saikin Bokumetsu (Dr.Mario&細菌撲滅, lit. "Dr. Mario & Bacteria Extermination") in Japan, is the first WiiWare video game of the puzzle genre to be released for the Wii by Nintendo and the fourth main installment in the Dr. Mario series. The title features both traditional Dr. Mario gameplay in addition to Virus Buster, a mini-game from Brain Age 2: More Training in Minutes a Day! and Brain Age: Concentration Training. Germ Buster has been modified for motion-sensing control rather than stylus control.

The title costed 1,000 Wii Points to download in all regions.

The Wii Shop Channel closed at the end of January 2019, therefore the title is no longer available to purchase.


In both modes, the traditional goal of the Dr. Mario series carried over into this title. Players maneuver Megavitamins tossed into a glass jar in order to destroy the Viruses. In order for a virus to be destroyed, it must be connected to at least four Megavitamins of the same color. In this version, either Dr. Mario or the player's Miis can toss viruses into the glass jar. Virus Buster can only be played with the Wii Remote.


In addition to the single-player mode, Dr. Mario features local and online multiplayer. The title took advantage of Nintendo Wi-Fi Connection for online matches between friends around the world. Players could download the multiplayer demo from a friend who owns the game, enabling players to compete when only one owns the title. Despite region encoding of the Wii, the multiplayer demo may be sent to a Wii system of a different region.

Wii eShop description[edit]

The doctor is in! Mario takes a break from his adventuring ways and once again dons his stethoscope for a new generation of germ-battling mayhem. In addition to the classic mode of using vitamins to exterminate viruses, you'll find two battle modes and an online multiplayer mode where you can hone your skills against players from around the world. Feel like challenging a friend who doesn't have Dr. Mario Online Rx? Then the WiiWare-exclusive Friend Battle Demo is just what the doctor ordered. Or maybe you'd like some help taking on those nasty Viruses? Try out Virus Buster, where four players can simultaneously move capsules simply by pointing at them with a Wii Remote controller. Any way you look at it, Dr. Mario Online Rx is a prescription for fun that everyone can enjoy!



Release Reviewer, Publication Score Comment
Wii Sammy Barker, Nintendo Life 7/10 "Dr. Mario looks great, sounds great and plays great, just like the original did 18 years ago, and the inclusion of online multiplayer adds value. Newcomers to the series will be thrilled, but puzzle veterans may be a little disappointed. Dr. Mario was and still is a very, very good puzzle game and that fact remains unchanged here. If you're a fan of Tetris or puzzle games in general then you will be delighted with this game. If you already own a copy of Dr. Mario on NES, Game Boy, SNES or N64 then think twice before picking this up unless online multiplayer really floats your boat."
Wii Dan Whitehead, Eurogamer 7/10 "It's certainly a decent enough block-dropping puzzler, even if most people probably would've preferred Tetris. Or a Virtual Console release for the SNES Dr Mario and Tetris compilation. Either way, 1000 Points feels a bit steep."
Compiler Platform / Score
Metacritic 72
GameRankings 72.95%


Soundx.png It has been suggested that audio and/or video file(s) related to this section be uploaded.
Please upload all related music, sound effects, voice clips, or any videos for this section. See the help page for information on how to get started.
Audio.svg Disc Channel
File infoMedia:Dr. Mario Online Rx Banner.mp3
Audio.svg Title
File infoMedia:DMOR Title.oga
Audio.svg Select
File infoMedia:DMOR Select.oga
Audio.svg Fever
File infoMedia:DMOR Fever.oga
Audio.svg Chill
File infoMedia:DMOR Chill.oga
Audio.svg Cough
File infoMedia:DMOR Cough.oga
Audio.svg Sneeze
File infoMedia:DMOR Sneeze.oga
Audio.svg Stage Clear (1-19)
File infoMedia:DMOR Stage Clear 1-19.oga
Audio.svg Stage Clear (20+)
File infoMedia:DMOR Stage Clear 20+.oga
Audio.svg Lose
File infoMedia:DMOR Lose.oga
Audio.svg VS Victory
File infoMedia:DMOR VS Victory.oga
Audio.svg Virus Buster - Fever
File infoMedia:DMOR Virus Buster Fever.oga
Audio.svg Virus Buster - Fever (Danger)
File infoMedia:DMOR Virus Buster Fever Danger.oga
Audio.svg Virus Buster - Chill
File infoMedia:DMOR Virus Buster Chill.oga
Audio.svg Virus Buster - Chill (Danger)
File infoMedia:DMOR Virus Buster Chill Danger.oga
Audio.svg Congratulations
File infoMedia:DMOR Congratulations.oga
Audio.svg Credits
File infoMedia:DMOR Credits.oga
Help:MediaHaving trouble playing?


Main article: List of Dr. Mario Online Rx staff


  • Virus Buster in its original form was designed to help players relax instead of training their brains in Brain Age 2. It even includes relaxing arrangements of the classic Dr. Mario music.
  • In the Virus Buster game, if the player presses A Button while their cursor is on a Mii while in game, it will say something such as, "Good luck, Dr. Mario!" or "The more bitter the medicine, the better!" Sometimes, the Miis will tell the player information concerning the actual gameplay, such as how many minutes have passed and how many capsules they've thrown. If the player presses A Button while their cursor is on a Virus, it smiles to the front.

External links[edit]