Dr. Mario (Gamewatch Boy)
In order to enter the game mode, the top button on the right must be pressed. The direction pad is one button and is used to select Game A or Game B. In Game A, to eliminate a virus, only three blocks of the pill/virus are needed. In Game B, four are required. In both game modes, just three blocks are needed to remove pills. The red buttons are identical and selects the levels 1 to 9. In level 1, there are three viruses to eradicate while in level 9, there are 19. Pressing the button which corresponds to the Game Boy's button starts the game.
The direction pad moves the pill to the left while both the red buttons on the right move it to the right. The button rotates the pill while the bottom button on the right hastens its descent.
The three types of viruses are distinguished from their matching pills by flashing. There are 5 points for killing each virus, 15 points for taking out two simultaneously, and 30 points for three or more. After beating level 9, the word "EXCELLENT" will appear. The player can repeat level 9 by pressing the button.