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The Toad doctor first appears in Mario & Luigi: Superstar Saga, where he is trying to help Mario recover from Bean Fever in Little Fungitown. However, since he does not have the appropriate medicine, he sends Luigi on a quest to get Crabbie Grass from Guffawha Ruins.
In Mario & Luigi: Partners in Time, the Toad doctor appears when Toadsworth contracts Shroomshock after being concerned that Princess Peach is lost in time and unsafe. Since he does not have a medicine, Mario has to get the Refreshroom to cure Toadsworth.
In the remake, he is redesigned to look more like the current depiction of Toads, and his headlight is centered.