From the Super Mario Wiki
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The purpose of the game is to tilt the Game Boy Advance to divide the people and the animals that fall into the hand to their proper side.
The player can get a combo if three members of the same species are placed into their area side. But if a member of a species is placed into the wrong area side or a species falls on the hand when another one is present on it, the sky will turn dark, lightning will strike the two areas and the player loses the game.