From the Super Mario Wiki
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Cambridge University, also known as simply Cambridge and more formally as the University of Cambridge, is a university in the United Kingdom, considered one of the oldest and best in the world. It is one of the locations visited by Mario through the Timulator in Mario's Time Machine, when Isaac Newton lived on campus as a fellow of Trinity. The Royal Society met at Cambridge at the time of Mario's visit. From them, he determines from them the historical significance of the apple he brought back from Bowser's Museum and returns it to Newton, its proper owner.