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Disable is Mewtwo's down special move in Super Smash Bros. Melee and Super Smash Bros. for Nintendo 3DS / Wii U, based upon the recurring Normal-type move from the Pokémon series. Mewtwo fires a beam from its eyes in the direction that it is facing, temporarily dazing any nearby opponents caught by it and damaging them; the opponent must be facing Mewtwo and at around its eye level for the move to work, however. The move also dazes opponents for longer if they have a higher damage percentage. In Super Smash Bros. Melee using Disable on an already dazed opponent causes them to fly off, though in Super Smash Bros. for Nintendo 3DS / Wii U this only deals more damage. If the move is used on an opponent in the air, then they will only briefly flinch.

In Super Smash Bros. for Nintendo 3DS / Wii U, Mewtwo's stance when using Disable is different than in Super Smash Bros. Melee, with its lower head position allowing the move to hit smaller opponents more easily.