From the Super Mario Wiki
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Mr. Dice are rarely encountered exclusively in Frantic Factory. Two Mr. Dice are found in a large room filled with giant toy blocks. Another one can be found in the room where Chunky Kong fights the Toy Monster; several Mr. Dice also compose the Toy Monster's body. Two more Mr. Dice can be found in Diddy Kong's puzzle room in the R&D Room.
A Mr. Dice can be defeated in one hit.