Because of their thorn-covered exterior, Mario cannot pick up durians. He can, however, kick them like a soccer ball, as F.L.U.D.D. explains in the game, although in real life, durians are a lot heavier than soccer balls. Despite the durian's spikes, Yoshis can still eat them, turning their skin and Juice purple, allowing them to turn enemies into purple forward-moving platforms.
Durians later appear in Donkey Kong Jungle Beat, which features a whole world (consisting of two levels, specifically Battle for Storm Hill and Aerie Fortress) known as the Durian Kingdom. Upon reaching the end of levels in this kingdom, Donkey Kong eats an oversized durian.
Durians reappear in Mario Party DS, in the minigame Hexoskeleton. After being hit two times, Dry Bones will start ground-pounding the arena, creating a force that may drop a durian. If Dry Bones ground-pounds one, he will be stunned for a while before he starts to ground-pound the arena again. If the player wins the minigame twice, the player will earn the Boss Trophies collectable.
In Super Mario Odyssey and the Nintendo 3DS and Nintendo Switch version of Captain Toad: Treasure Tracker, durians are spit out by Cookatiel in her rematch battle for the former, and throughout Cookatiel's Sizzling Sprint in the latter.