From the Super Mario Wiki
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The Heart Box appears in the Game Boy Advance game Wario Land 4. It is a box similar in shape and size to the Jewel Piece Box and the CD case. When opened, a 500 Coin drops out, and a giant heart that changes color with a crown hovers above the open box. If Wario collects it, his health meter will be fully replenished. There are one of these to find in each level, excluding the Golden Passage. Their positions change with the Game Mode.