It's up to the player to find the critical one. To identify who it is, the player must move the cursor from patient to patient, and see which one's heart beat is different from all the others. This depends on how the controller rumbles. If the rumble is turned off, heartbeat symbols are shown on-screen above each patient instead. If the player gives a pill to the right patient, the player gets another set of them and repeat. For the first set, the player is given twenty seconds and for each new set, the time limit decreases by one second until set sixteen, which gives the player five seconds.
If the player does not do it in time, the one who was ill will pass out, while the other ones look at them. If the player gives the pill to the wrong patient, they will have a question mark on their head, instead of glowing, and the critical one passes out. Both ways include the ill one passing out, and the minigame ends with sirens wailing in the distance.
The game ends as well when a score of 99 is reached.
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