From the Super Mario Wiki
“To all Diamond City residents! We are now hiring experiment subjects! Experiments are guaranteed to be 100% not-entirely-lethal.”
Penny Crygor, most commonly just known as Penny, is Dr. Crygor's granddaughter. Her first appearance is in WarioWare: Smooth Moves. She admires her grandfather and wants to grow up to be a great scientist, though she also desires to become a famous singer. She attends Diamond Academy.
Some day, Penny enters a competition called the "Invent-Off" at the Diamond Academy and is put against her grandfather to see who is the best inventor. After what appeared to be a mental fight between the two, Penny pulls out her winning invention (a motorcycle) out of thin air which, for some reasons, knocks Dr. Crygor down. Penny then takes one of Mike's head-mounted microphones and decided to sing a song to the cheering crowd.
In WarioWare: D.I.Y., she helps the player and Wario create microgames. As such, she leads the game's tutorials. During the create a game tutorial she is be paired up with Wario who serves as her student as well as the player. She frequently makes sarcastic quips toward Wario's intelligence and patience, though she is quick to apologize when Wario gets offended.
Penny appears as the host of the multiplayer minigame Fruit, where she give tips to the "agent" player and react to setpieces (such as reactivating the lights when they're turned off).
Like most of the other WarioWare developers, a bowling pin modeled after her is featured in the Bowling minigame.
As with the other WarioWare characters, Penny makes an appearance in Miiverse Sketch Masterpiece Collection, a series of video showcasing pictures of often questionable quality made in the game's Miiverse Sketch mode. Penny's video is themed after drawings of Prince Shōtoku, an important ruler in Japanese history.
Rhythm Tengoku: The Best+
Penny makes a cameo appearance in the Rhythmware challenge set of Rhythm Tengoku: The Best+. She and Crygor appears in the background during the set's version of Fillbots, which now features Mike as one of the models of robots being filled with liquid.
Miiverse Sketch Masterpiece video
Game & Wario character card
-Dr. Crygor's granddaughter