Sphinx may refer to:
- The Sphinx, a real-life monument appearing in various Super Mario media, most notably Mario is Missing! and the Club Nintendo comic "Mario's Picross".
- Sphinx, a character in Wario: Master of Disguise.
- Sphinx Jr., an enemy appearing in the same game.
- Sphinx Zō, a character in Super Mario-kun volume 6.
- Sphynx, a character in Super Mario Odyssey.
- Jaxi, a rideable sphinx-like creature in Super Mario Odyssey.
- Yoshi Sphinx, a level in Paper Mario: Sticker Star.
- The Hammer Bros. Sphinx, a landmark in the Mario Kart series.
- Gao, an enemy appearing in Super Mario Land, modeled after the real life Sphinxes.
- King Totomesu, a boss appearing in the same game, also modeled after a Sphinx.
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