Dr. Mario World

Dr. Mario World is a puzzle game in the Dr. Mario series for and  smartphones. The game was originally set to release on July 10, 2019, but ended up being released a day earlier on July 9. It is a free to download game with in-app purchases that was co-developed by Nintendo, LINE, and, and was available initially in 59 countries/regions including Japan and the United States. The game supports multiple languages including Japanese and English. Dr. Mario World is the second Mario game for mobile devices, following Super Mario Run, though it is the first free-to-play mobile game featuring microtransactions and gacha mechanics in the Mario series. Pre-registration for the game opened on July 1. Like Super Mario Run, the game requires a constant internet connection to play.

Dr. Mario World takes advantage of the touchscreen controls of the smartphone, where players can drag capsules with the touchscreen to eliminate viruses, though the core gameplay is slightly tweaked in the single player as opposed to prior Dr. Mario titles in that players solve puzzles with a limited number of capsules rather than infinite capsules against a time limit. New gameplay elements include four introduced colors of viruses: green, light-blue, purple, and pink viruses, which occur mixed in the regular red, blue, and yellow viruses later in the game. Dr. Mario World features the debut of playable Mario characters as doctors than prior Dr. Mario games. These doctors have special abilities which help clear levels more easily. In addition, doctors can be paired with a wide variety of assistants, which constitute primarily of generic Mario enemies. As well as having a single player mode, Dr. Mario World introduces a competitive versus mode, where players battle against opponents online in a gameplay style similar to the traditional Dr. Mario games.

Story
A virus outbreak has occurred in the Mushroom Kingdom, infecting Koopa Troopas, Toads, and Shy Guys, where Dr. Mario hunts down viruses to save the locals. Dr. Toad instructs Dr. Mario on how to eliminate viruses in the first demo level, featuring only red viruses. By the 3rd (11th in version 1.10) level, Princess Peach notices that the Toads need her help while Bowser wants to take care of the viruses affecting his minions himself, so they join Dr. Mario as playable characters.

Gameplay
As with previous Dr. Mario games, the main and most common objective is to eliminate all of the viruses on the screen by connecting capsules of the same color to each of them, although instead of the capsules descending, the game's gravity is directed upwards with the viruses positioned towards the top of the screen. The player first drags a capsule from the bottom of the screen onto the field to use it, and can drag it again to move it or increase its "falling" speed, or tap it to rotate it horizontally or vertically; if there is an open space for the capsule to fit through, players may drag the capsule towards that open space as well. Viruses are eliminated if three (as opposed to four) or more of the same color are matched. If a player uses a half of a capsule to eliminate viruses, the other half remains, and players can drag it around as an ordinary capsule if it is free to go up the screen. Players earn a rainbow capsule if they make seven matches that eliminate viruses; these rainbow capsules can be used in tandem with pills of any color to eliminate viruses, though they take up only one tile on the screen. The classic red, blue, and yellow viruses return, while new green, purple, light-blue, and pink viruses make their debut.

Depending on the level, various obstacles may appear on the field, including Empty Blocks and Brick Blocks and viruses can be hidden inside of the Brick Blocks. Different-colored shells and exploders can also appear among the viruses which, when matched with capsules of the same color, clear out viruses on the same row and eliminate surrounding viruses, respectively. In the same manner of activating the aforementioned items, players can obtain a skill charger that fully fills out their doctor's skill meter. Viruses can be trapped in ice, which requires two clearings to destroy them, encased in bubbles, which shield them from capsules once before they disappear, or trapped in cages, being released only after clearing a lock on the field.

Special items can be used prior to entering a stage and while in the middle of a stage which aids players to clear the stage. Dr. Toad gives out free items for a trial use, but after the single use, players need to purchase the items with diamonds or coins.

Game modes
Dr. Mario World has two main modes – stage mode and versus mode – a daily mode, and events. Stage mode serves as the game's single player mode, while versus mode serves as the game's multiplayer mode. Versus mode is unlocked when players have cleared Stage 5 (20 in old versions).

Stage mode
Stage mode is the mode players first start through and requires players to fulfill various objectives in order to clear stages. The most common objective is to eliminate viruses, though other objectives are include obtaining Virus Coins hidden in Brick Blocks. Stages are grouped into worlds, beginning with five – which are in order grass-, desert-, beach-, ghost-, and sky-themed – with more to be added in the future. Each world has two areas, which have 20 stages in each area. Each world has its own set of challenge stages, in which players need to clear the stage before the time limit runs out. Unlike prior Dr. Mario games, players are limited to a certain amount of capsules per stage.

In order to play a stage, the player needs to have at least one heart. A heart is regained automatically every 30 minutes, although players can purchase hearts with diamonds or clear a stage for a free heart. In the first 20 stages, players have an infinite number of hearts; afterwards, players are granted a max number of five hearts. Diamonds can also be used to obtain items, obtain new doctors and assistants, and to continue a stage should a player failed to clear the objective after running out of capsules or time (although only two continues are allowed per attempt). Diamonds can be purchased through the app with real money. When a player clears a stage, they earn coins, a heart, and a number of stars depending on how many capsules are left when they have cleared; they can earn a max number of three stars for the best score. If a player retries a stage too many times, Dr. Toad uses a free hammer on a tile for the player.

Stage mode features Doctor's Orders, which are a list of extra objectives players can complete for bonus coins. Some objectives can be filled in both stage mode (which extends to Daily Booster and Skill Summit) and versus mode while others are exclusive to either. Once the Doctor's Orders objectives are completed, it takes 6 hours (20 hours prior to version 1.1.0) to receive new ones, while skipping objectives takes 1 hour (8 hours prior to version 1.1.0).

Versus mode
In versus mode, players pit against other human opponents online or against their friends, and it plays similarly to the multiplayer modes of previous Dr. Mario titles. The goal for players is to clear viruses in their grid to send viruses to their opponent's side; players lose if they obtain enough viruses that cross the bottom line of the stage. When players clear viruses, their attack meter fills; when the attack meter is full, players can send a row of viruses to their opponent. The number of viruses is dependent on the doctor's attack power; the higher their attack is, the more viruses they can send, but their attack meter fills more slowly than weaker doctors. Players can view their opponent's grid, as well as a dotted line indicator showing how far viruses are down on their opponent's stage. Additionally, players have a chance to prevent opponents from sending viruses to them; the higher their doctor's defense stat is, the likelier the attack will be defended against.

Players are sorted into tiers, which serves as the game's matchmaking feature. Players earn battle points if they win matches and lose battle points if they do not. When enough battle points are earned, players ascend tiers and the higher their tier is, the better rewards they earn for winning. Players earn keys for a battle box if they win battles, and if they have enough keys, they can open battle boxes to obtain random loot in them such as coins, hearts, tickets for assistance, etc., including special assistants exclusive to higher tier battle boxes. Battle boxes can be open once every 10 hours after they have been opened, but by using diamonds, players can immediately obtain a new box to unlock.

Once every two to three months, the game is updated to add a new season, which adds new tiers.

Daily Booster
The Daily Booster, introduced in the version 1.3 update, replaces the Daily Gift. The player eliminates viruses to earn coins and doc tokens. Once all of them have been eliminated, everything on the stage is eliminated, and new viruses appear after a few seconds. If an object touches the bottom line, the game ends. The player gets four coins for every virus eliminated, and one doc token for every 45 viruses eliminated. It can be played for free once per day, and can be played again using diamonds, with the rewards being received at a tripled rate: each virus rewards twelve coins and each doc token is rewarded for every 15 viruses eliminated. Once a triple-reward game is finished, the player must wait until the next day to play this mode again.

Prior to version 1.3.5, a single music theme plays during both the Daily Booster rounds and the results screen. After that update, the theme that plays during the round has changed, with its old theme only played at the results screen.

Starting from version 1.4.0, the Daily Booster received a few changes. The following changes are made:
 * Players start with 20 capsules instead of 30 or 33 capsules.
 * Each round starts with more viruses and objects on the field compared to the previous updates.
 * After all the viruses are eliminated in a round, two capsules are rewarded instead of five.
 * Only two colors of viruses and objects are available. Since the change, only red and blue are available but as of version 2.1.0, any two colors between red, blue and yellow are randomly selected.
 * The objective shown at the start of the first round will display infinite viruses instead of the number of viruses in the first round.

Skill Summit
The Skill Summit, introduced in the version 2.0 update, is placed next to Stage mode or Versus mode. This mode is only available after the player has finished Stage 20 in Stage Mode. In this mode, a few doctors are assigned as mentor doctors, and each stage will feature one of those doctors. Each stage in this game is called a summit, and there are four types of summits: Basic, Intermediate, Advanced and Special. For the first three types, players can choose a doctor of their own, but in the Special summits, players must have at least one of the two eligible mentor doctors before they can play that summit. In regards to the player's choice of doctor, players cannot choose the same doctor as the mentor doctor. For example, if the mentor of the stage is Dr. Baby Mario, the player will not be allowed to use that doctor. Similarly, variations of that doctor are prohibited, so in Dr. Baby Mario's case, Dr. Mario, Dr. Fire Mario or 8-bit Dr. Mario cannot be selected as the doctor.

Similar to stage mode, the player needs to have at least one heart before they can play a summit. In each summit, players are assigned various objectives and a limited amount of capsules to accomplish those objectives. Should a player run out of capsules before the objective(s) are completed, diamonds can be used to continue that summit for up to two times. Each summit plays similarly to a stage in stage mode, but the difference is that a mentor doctor is displayed at the top-left corner with a meter. This meter will fill each time a capsule is added to the stage, and once it is fully filled, the active capsule will be replaced by that mentor doctor's icon. The player must activate that mentor's skill before they can introduce more capsules to the stage, although other functions can still be used, such as utilizing capsules on the stage, use in-stage items or activating their doctor's skill if it is filled. The mentor's skills may differ from their doctor's skill, typically with reduced effect. For example, while Dr. Baby Peach's skill normally change the next three capsules to rainbow capsules, Dr. Baby Peach's skill as a mentor instead only change one next capsule to a rainbow capsule.

After clearing a summit, players will be awarded Kudos, which are functionally the same as clear stars in stage mode in that reaching specified benchmarks in the score will reward up to three of them. Each new kudos obtained will reward the player with 50 coins, for up to 150 coins. In addition to this, clearing a stage for the first time will reward a player with a heart, no matter the score. Rewards can be earned by reaching a specific number of kudos, which can include stage items, doc tokens, staff tickets, 10% score boost in Stage Mode or even a new doctor. Players are also rewarded if they cleared all stages in each type of summit, which can include +2 capsules boost in Stage Mode, +60% faster skill meter charge, Staff Tickets and 100 doc tokens. The Stage Mode boosts earned from Skill Summit are bonuses specifically for Stage Mode, and they last for 24 hours starting from the time each bonus is obtained, but it only takes effect in stages up to a specified World. The duration of the bonuses are cumulative, meaning that if the player has a bonus that is still active, obtaining another of that same type of bonus will extend the period for another 24 hours.

Each season of skill summit lasts for two weeks, after which new skill summits will replace the old summits and the rewards and kudos are refreshed.

Clinic Event
For this event, the player needs to do the following steps for the event:  
 * 1) Examine the patient.
 * 2) Eliminate the viruses.
 * 3) Clear all stages with three stars!

Once a step is cleared, the player earns rewards as well as a medal with the patient on it. The character depends on the current season:
 * Season 1: Blue Toad
 * Season 2: Goomba
 * Season 3: Spike
 * Season 4: Koopa Troopa
 * Season 5: Piranha Plant
 * Season 6: Green Toad
 * Season 7: Paragoomba
 * Season 8: Koopa Paratroopa
 * Season 9: Shy Guy
 * Season 10: Blooper

Collect Clear Stars
In Collect Clear Stars!, the player needs to collect stars and receive rewards. However, they do not count if they were previously earned.

Eliminate the viruses!
In Eliminate the viruses!, the player eliminates viruses in stages and receive rewards. They only count in stage mode.

Doctors
So far, Dr. Mario World features 40 playable characters. Each playable character offers a unique special skill that can be activated during gameplay. Players start with Dr. Mario when they first play the game and unlock Dr. Bowser and Dr. Peach when they reach Stage 11; if players pick one of the three characters, the other two characters become unavailable. As of version 2.0.0, Dr. Toad is earned as another doctor when players have beaten Stage 20. Players can purchase new doctors with coins, diamonds, staff tickets or doc tokens in the Staffing menu of the game (The exception is Dr. Dry Bowser, who is as of now only available as occasional in-app purchases), although the doctors are obtained randomly and duplicates may occur. If players receive duplicate characters, it goes towards that doctor's skill level and players stop earning duplicates if a particular character has a maxed out skill level that requires 30 duplicates of that available doctor. Reaching new skill levels will also make the skill meter fill faster for that doctor in stage mode.

More doctors are planned to be added via software updates.

Doctor stats
The following are the stats for all doctors in Versus mode. The bomb displays how many rows of viruses the doctors can send to their opponents, the speed lists how many viruses or capsules are required to be eliminated for the meter to fill, and the defense represents the chance a doctor has to block against the bomb displayed. The rate skill meters are charged are hidden and differ from each doctor.

Assistants
So far, Dr. Mario World features 61 assistants. Assistants, like the doctors, have unique skills that aid the player. Up to two assistants can be selected at once. Like doctors, these characters' skills level up with play or by obtaining duplicates from the Staffing menu. Goomba is earned as the first assistant when players reach Stage 20.

More assistants are planned to be added via software updates.

Viruses
While the red, blue, and yellow viruses return from previous Dr. Mario titles, Dr. Mario World introduces four more colors of viruses: green, light-blue, pink, and purple.

Other characters

 * Dorrie
 * Toads
 * Stone-Eyes
 * Ice Bros
 * Bone Goombas
 * Lava Bubbles
 * Whomp
 * Foos
 * Deep Cheeps

Worlds
There are twenty worlds total in the base game for Dr. Mario World. Each world is sorted into two areas, with each area containing 20 stages. Each world additionally contains three challenge levels which reward players with coins upon completion. New worlds are planned to be added in an update. When the player clears the first area of a world, they earn a coin or assistant reward. When a player clears the second area of a world, represented by a Goal Pole, they earn a staff ticket for use in the Staffing menu that can unlock new doctors or assistants, as well as a silver medal. If they earn all stars in a world, they earn a gold medal for that world; and clearing a special stage in a world rewards a platinum medal, 1000 coins and a doctor. In every special stage, there are blue, yellow, and pink viruses, except in World 13, where the red virus replaces the pink one. Several of the worlds' designs take some inspiration from the New Super Mario Bros. series.

More worlds are planned to be added in future updates.

Virus Vid


To promote Dr. Mario World, Nintendo released a series of short videos on social media featuring the viruses performing various activities, beginning on June 18, 2019 and ending on July 10, 2019, on a daily basis.

Animal Crossing: Pocket Camp
To celebrate the release of Dr. Mario World, three T-shirts based on the blue, red, and yellow viruses were made available to players for free in Animal Crossing: Pocket Camp on July 19, 2019.

Critical reception
At launch, Dr. Mario World received generally mixed to somewhat negative reviews. Critics were somewhat divided but leaned positively on its puzzle aspect and its multiplayer mode, but near unanimously criticized its overabundance of microtransactions and its online requirement. It currently holds a score of 58 on Metacritic based on sixteen reviews and a score of 55.94% on GameRankings based on eight reviews.

Chris Carter of Destructoid gave the game a 6/10, praising the accessibility and puzzles the game has to offer, but criticized the microtransactions, claiming "I've been playing mobile games consistently since Flight Control in 2009; so you could say I've had many encounters with energy systems and the like. The situation is definitely case-by-case, nuanced, and depending on the game the juice can absolutely be worth the squeeze. But seeing cute Mario characters reduced to this, with all of the psychological tricks in the book thrown in, is depressing. Just energy, just "you can finish this hard level if you pay," or just gacha would have been a lot as it is." In a review without a score, Ben Bertoli of IGN expressed skepticism over the change in gameplay compared to previous entries in the series, and was slightly more critical of the microtransactions, stating "While it doesn't make it unplayable, to be sure, it makes it very clear from the get-go where this Dr. Mario's priorities lie." He concluded that it was still a fairly decent game to play for those who enjoy puzzle games. In an even more negative review, Glen Fox of Gamezebo gave the game a 2/5, criticizing practically everything about the game; he called the puzzles "artificial difficulty" and "uninspired," and raised a larger furor over the microtransactions, stating that he never expected Nintendo to engage in such predatory practices.

In stark contrast to other critics, Chris Scullion of Nintendo Life gave the game an 8/10, and praised mainly the multiplayer mode. While he agreed with other critics that the single-player mode was muddled with excessive microtransactions, he believed that the gameplay was fitting for a mobile device, and believed the multiplayer mode would be the game's highlight.

On the Google Play storefront, Dr. Mario World currently has an average user score of 3.9 out of 5, while on Apple's App Store, it has an average user score of a 4.5 out of 5.

Sales
Dr. Mario World has received 2 million downloads in the first 72 hours of its launch. It additionally received $100,000 from its in-app purchases. While it had only half of the downloads Super Mario Run had in the same time window, which was exclusive only to iOS at launch, and it is the lowest grossing Nintendo mobile game at this launch window, Dr. Mario Worlds revenue is comparable to other games in its genre such as Candy Crush Friends Saga; Dr. Mario World generated 75% of the revenue compared to Candy Crush Friends Sagas $137,000 in the same markets.

Dr. Mario World has reached 5 million downloads globally and players have spent $500,000 on in-app purchases in its first week, which is comparable to the top 25 puzzle games in Dr. Mario World's genre; Toon Blast from Peak Games, for example, grossed approximately $325 million in 2018, yet saw just $90,000 in its first week. Dr. Mario World charted as the #1 free iPhone app in Japan and #6 in the US.

Mobile app store description

 * Match 3 puzzle versus viruses!

■ Use your puzzle skills to eliminate pesky viruses!


 * Match capsules with viruses and watch them disappear! Simply match three objects of the same color vertically or horizontally to clear them.
 * Luckily, Dr. Mario and friends have virus-busting skills, and you can use leftover half-capsules to strategically zero in on especially meddlesome viruses.
 * Take your time, because each puzzling configuration of viruses must be cleared using a limited number of capsules. Keep calm to plan your approach, and you'll rid Dr. Mario's world of viruses in no time!

■ Paging Dr. Mario!


 * A colorful cast of viruses has Dr. Mario's world in a panic! Dr. Mario and friends have put on lab coats and grabbed capsules! Now they're ready to eliminate those unruly viruses.
 * Dr. Mario isn't the only one on call—Dr. Peach, Dr. Bowser, and others are on duty. Staff up with assistants like Goomba, Koopa Troopa, and Buzzy Beetle to help your doctors out with additional skills.
 * Doctors and assistants have various virus-busting skills, so experiment to find a combination that suits your style and pace.
 * Hundreds of stages over many different worlds are ready for you to save! New worlds, new doctors, and more will be delivered on a regular basis.

■ Play together with friends and family around the world!


 * You're not in this alone—send and receive stamina-giving hearts to use in stage mode! Then, show off your puzzle-solving progress.
 * In versus mode, you can turn up the intensity on your virus-busting by challenging others to a one-on-one showdown—without using hearts!
 * Find the right combo of doctor and assistants and aim for victory online to earn battle points and increase your tier!

Notes: 
 * This game is free to start, with optional in-game purchases.
 * Persistent Internet and compatible smart device required. Data charges may apply.
 * May contain advertising.
 * For information about our ads, please see the “How we use your information” section of the Nintendo Privacy Policy.

Bowser

 * "My minions! Grrr... I'll take care of all these viruses!"

Dr. Toad

 * "Oh no! Viruses have gotten everywhere! We'd better do something."
 * "Let's eliminate the viruses!"
 * "To eliminate a virus, you need to use a blue."
 * "I'll show you how to do it!"
 * "While holding the capsule, drag it onto the stage. If you let go, it will begin to rise toward the top of the screen."
 * "If the capsule collides with a virus or another object, it will stop moving."
 * "Once it stops moving, if blue colors match blue or blue, the virus will be eliminated!"
 * "Tap a capsule to rotate it."
 * "It can be helpful to rotate the capsule before moving it into the stage, too!"
 * "Tap, hold, and drag the capsule to move it."
 * "You can't move a capsule back toward the bottom of the screen, so be careful!"
 * "OK! We eliminated all the viruses. Go, us!"
 * "You have a blue of capsules. The number in the top right of the screen shows how many are left."
 * "Eliminate all the viruses before you run out of capsules to clear the stage!"
 * "If you run out of capsules... Well... Too bad. You'll have to try again!"
 * "You'd better pay attention to how many capsules you have left!"
 * "Look at that! Your next capsule has turned into a blue!"
 * "Rainbow capsules are special. They can match with objects of any color."
 * "After you make seven matches that eliminate viruses or capsules, one will appear."
 * "There's a blue on both the left and right sides of the stage that shows how many matches you've made."
 * "Use the rainbow capsule to eliminate a virus of any color!"
 * "You can use items now!"
 * "Tap an item to see what it does."
 * "If you select an item before starting a stage, it will be used when the stage begins."
 * "To use an item, you usually need diamonds or coins. But this time, I gave you an item for free. Give it a try!"
 * "That filled up your skill meter. Let's go ahead and use it!"
 * "Tap the skill button!"
 * "You now have access to all the items. I hope they'll help in your virus hunt!"
 * "Now that all the viruses are gone, our friends are back!"
 * "But wait! I see more viruses causing mischief up ahead. We've got to keep going!"
 * "And now the virus hunt begins!"
 * "Please select the doctor you want from among these three choices."
 * "This item, the blue, will charge up your blue."
 * "Let's try it out. First, match three pieces of the same color."
 * "Look at that! You've still got half a capsule there."
 * "You can tap and hold it to move it around, just like a full-sized capsule."
 * "Put half-capsules in empty spaces. You want to make the best use of your capsules that you can!"
 * "Now you can use the blue! This'll let you clear out all the capsules on the stage at once." (removed in version 1.4.0)
 * "You can now use the blue! Use it to change the color of your next capsule." (since version 1.4.0)
 * "You can now use the blue! It'll fill your doctor's skill meter in an instant."
 * "You can now use the blue! Select a row and you can clear it immediately." (since version 1.3.0)
 * "Here, take this one. Come on, give it a try!"
 * "You've entered a new area!"
 * "From here on, we'll need the help of blue characters."
 * "To add your new recruit to the team, tap the blue button."
 * "Characters are divided into two categories: blue and blue."
 * "Your doctor is your main character. You can choose one-and only one-at a time!"
 * "Each doctor has their own unique blue."
 * "Assistants? Well, they help doctors, of course. You can select two."
 * "The assistants you choose have blue that aid the doctor in the fight against viruses."
 * "Want to know what effect an assistant will have? Just tap the assistant to see."
 * "Now it's your turn. Choose an assistant."
 * "You've made your team! Let's try clearing a stage now."
 * "blue, the blue menu, and other features are now unlocked!"
 * "Welcome to versus mode! Here, you can compete with people from around the world in real-time, online battles."
 * "Depending on the outcome of these matches...you'll gain or lose battle points."
 * "As your battle points go up, you'll rise in tier, and be able to earn bigger rewards!"
 * "Let's head on over to versus mode and give it a try!"
 * "You battle by sending viruses to your opponent. But watch out! They can send viruses your way, too."
 * "If the stage fills with enough viruses that they cross the bottom line, you'll blue the match."
 * "Your blue will fill as you eliminate viruses."
 * "Your attack meter is full! When that happens, you'll attack your opponent with viruses."
 * "Look at that! Your attack was a success. Your opponent's stage got hit with a new row of viruses!"
 * "How many rows you send depends on your doctor's blue."
 * "The higher it is, the stronger the attack-but the longer it takes to charge up!"
 * "Different doctors fill up their attack meters at different rates. Try out some doctors, and find the one that you like!"
 * "Check out the map at the top right. It shows your opponent's stage."
 * "This dotted line shows how far down the viruses have gotten on your opponent's stage."
 * "Keep an eye on how your opponent is doing...and send over viruses at just the right time!"
 * "Be careful! Your opponent's attack meter is full!"
 * "What-? How did you DO that? You defended against their attack!"
 * "Oh, right! I forgot. You have a chance to defend against any attack."
 * "The higher your doctor's blue, the better chance you have to defend!"
 * "Your blue is full! Let's try using a skill."
 * "Each doctor has a skill of their own. There are lots of different ones!"
 * "Well, that should do you. You're ready to try out what you've learned on a real opponent!"
 * "How's the virus hunt going? I'd like to show you a little technique that might just help..."
 * "Get good at this, and you'll be eliminating viruses like a pro!"
 * "See how these viruses are surrounded by blocks?"
 * "If you tap and hold a capsule, you can drag it between the blocks!"
 * "See? No matter the obstacle, as long as there is space, you can put the capsule there."
 * "But be careful! If there's not enough space, you can't place a capsule!"
 * "Use this trick to your advantage and take care of those viruses!"
 * "Here's a little something to help you clear that tough stage!"
 * "Wow, somebody doesn't look so good... It's got to be those pesky viruses!"
 * "Give the patient an exam and see what you can do to make them feel better!"

Narrator

 * "Viruses have invaded-everywhere!"
 * "Both the Toads and Bowser's minions have been sent into a panic!"
 * "Hunt down all the viruses and save everyone!"
 * "The viruses must be stopped-THAT they can all agree on. Mario, Peach, and Bowser don their lab coats and head toward adventure! The virus hunt begins..."

Princess Peach

 * "The Toads are in danger... I have to help!"

Pre-release and unused content
Unused assets have been extracted from the game, showing King Boo and Morton Koopa Jr. doctors, and a Bone Goomba, Cooligan, Dino Piranha, Freezie, Galoomba, Ice Bro, Lava Bubble and Whomp assistants , and text strings for Magikoopa and King Kaliente assistants.

There are also medals featuring Boo indicating future Clinic Events, a golden ticket to unlock costumes for characters , medals themed to Super Mario Galaxy, and a black, spiky, Fuzzy-looking creature wearing a surgical mask.

References to other games

 * Super Mario series: This game's six worlds, as well as World 9, World 10 and World 11, are commonly featured across the Super Mario platformers.
 * Super Mario Bros.: The coin sound effect is directly taken from this game's NES version.
 * Dr. Mario: Dr. Mario's sprites from this game are reused for a separate playable doctor, 8-Bit Dr. Mario. The music heard in the stage select and versus mode menu are the respective arrangements of the title screen from this game. The music heard in the staffing screen is an arrangement of the mode menu screen from this game. Two arrangements of Fever is used in stage mode and in versus mode, while an arrangement of Chill is used for the stage mode's challenge stages.
 * Tetris & Dr. Mario: The music heard during Dr. Toad's demo tutorial in World 1's first area is an arrangement of Music 1 from the Mixed Match mode from this game.
 * Dr. Mario 64: The music in the Skill Summit menu uses an arrangement of Cube (Cough), and in Skill Summit stages uses an arrangement of Que Que (Sneeze).
 * Super Mario Galaxy: A Star Bunny and Honey Queen appear as assistants. Dino Piranha's planet, the Starshroom, and the Comet Observatory appear on the World 8 map.
 * New Super Mario Bros. Wii: Dr. Wendy's artwork is based on Wendy's artwork from this game, albeit mirrored.
 * Donkey Kong Country Returns: One of Dr. Donkey Kong and Dr. Diddy Kong's artworks is based on Donkey and Diddy Kong's artwork from this game.
 * New Super Mario Bros. U: Dr. Ludwig's artwork is based on Ludwig's artwork from this game.
 * Mario Party 10: Most of the characters' victory, losing, and idle animations are taken from this game.
 * Super Smash Bros. Ultimate: One of Dr. Roy's sprites is based on Roy's official render from this game.