Dr. Mario World

Dr. Mario World is a puzzle game in the Dr. Mario series for and  smartphones. The game was originally set to release on July 10, 2019, but ended up being released a day earlier on July 9. It is a free to download game with in-app purchases that was co-developed by Nintendo, LINE, and, and was available initially in 59 countries/regions including Japan and the United States. The game supports multiple languages including Japanese and English. Dr. Mario World is the second Mario game for mobile devices, following Super Mario Run, though it is the first free-to-play mobile game featuring microtransactions and gacha mechanics in the Mario series. Pre-registration for the game opened on July 1. Like Super Mario Run, the game requires a constant internet connection to play.

Dr. Mario World takes advantage of the touchscreen controls of the smartphone, where players can drag capsules with the touchscreen to eliminate viruses, though the core gameplay is slightly tweaked in the single player as opposed to prior Dr. Mario titles in that players solve puzzles with a limited number of capsules rather than infinite capsules against a time limit. New gameplay elements include four introduced colors of viruses: green, light-blue, purple, and pink viruses, which occur mixed in the regular red, blue, and yellow viruses later in the game. Dr. Mario World features the debut of playable Mario characters as doctors than prior Dr. Mario games. These doctors have special abilities which help clear levels more easily. In addition, doctors can be paired with a wide variety of assistants, which constitute primarily of generic Mario enemies. As well as having a single player mode, Dr. Mario World introduces a competitive versus mode, where players battle against opponents online in a gameplay style similar to the traditional Dr. Mario games.

Story
A virus outbreak has occurred in the Mushroom Kingdom, infecting Koopa Troopas, Toads, and Shy Guys, where Dr. Mario hunts down viruses to save the locals. Dr. Toad instructs Dr. Mario on how to eliminate viruses in the first demo level, featuring only red viruses. By the 3rd (11th in version 1.10) level, Princess Peach notices that the Toads need her help while Bowser wants to take care of the viruses affecting his minions himself, so they join Dr. Mario as playable characters.

Gameplay
As with previous Dr. Mario games, the main and most common objective is to eliminate all of the viruses on the screen by connecting capsules of the same color to each of them, although instead of the capsules descending, the game's gravity is directed upwards with the viruses positioned towards the top of the screen. The player first drags a capsule from the bottom of the screen onto the field to use it, and can drag it again to move it or increase its "falling" speed, or tap it to rotate it horizontally or vertically; if there is an open space for the capsule to fit through, players may drag the capsule towards that open space as well. Viruses are eliminated if three (as opposed to four) or more of the same color are matched. If a player uses a half of a capsule to eliminate viruses, the other half remains, and players can drag it around as an ordinary capsule if it is free to go up the screen. Players earn a rainbow capsule if they make seven matches that eliminate viruses; these rainbow capsules can be used in tandem with pills of any color to eliminate viruses, though they take up only one tile on the screen. The classic red, blue, and yellow viruses return, while new green, purple, light-blue, and pink viruses make their debut.

Depending on the level, various obstacles may appear on the field, including Empty Blocks and Brick Blocks and viruses can be hidden inside of the Brick Blocks. Different-colored shells and exploders can also appear among the viruses which, when matched with capsules of the same color, clear out viruses on the same row and eliminate surrounding viruses, respectively. In the same manner of activating the aforementioned items, players can obtain a skill charger that fully fills out their doctor's skill meter. Viruses can be trapped in ice, which requires two clearings to destroy them, encased in bubbles, which shield them from capsules once before they disappear, or trapped in cages, being released only after clearing a lock on the field.

Special items can be used prior to entering a stage and while in the middle of a stage which aids players to clear the stage. Dr. Toad gives out free items for a trial use, but after the single use, players need to purchase the items with diamonds or coins.

Game modes
Dr. Mario World has two main modes – stage mode and versus mode – a daily mode, and events. Stage mode serves as the game's single player mode, while versus mode serves as the game's multiplayer mode. Versus mode is unlocked when players have cleared Stage 5 (20 in old versions).

Stage mode
Stage mode is the mode players first start through and requires players to fulfill various objectives in order to clear levels. The most common objective is to eliminate viruses, though other objectives are include obtaining Virus Coins hidden in Brick Blocks. Levels are grouped into worlds, beginning with five – which are in order grass-, desert-, beach-, ghost-, and sky-themed – with more to be added in the future. Each world has two areas, which have 20 stages in each area. Each world has its own set of challenge stages, in which players need to clear the stage before the time limit runs out. Unlike prior Dr. Mario games, players are limited to a certain amount of capsules per level.

In order to play a level, the player needs to have at least one heart. A heart is regained automatically every 30 minutes, although players can purchase hearts with diamonds or clear a level for a free heart. In the first 20 levels, players have an infinite number of hearts; afterwards, players are granted a max number of five hearts. Diamonds can also be used to obtain items, obtain new doctors and assistants, and to continue a level should a player fail an attempt (although only one continue is allowed per attempt). Diamonds can be purchased through the app with real money. When a player clears a stage, they earn coins, a heart, and a number of stars depending on how many capsules are left when they have cleared; they can earn a max number of three stars for the best score. If a player retries a stage too many times, Dr. Toad uses a free hammer on a tile for the player.

Stage mode features Doctor's Orders, which are a list of extra objectives players can complete for bonus coins. Some objectives can be filled in both stage and versus mode while others are stage mode-exclusive. Once the Doctor's Orders objectives are completed, it takes 6 hours (20 hours prior to version 1.1.0) to receive new ones, while skipping objectives takes 1 hour (8 hours prior to version 1.1.0).

Versus mode
In versus mode, players pit against other human opponents online or against their friends, and it plays similarly to the multiplayer modes of previous Dr. Mario titles. The goal for players is to clear viruses in their grid to send viruses to their opponents side; players lose if they obtain enough viruses that cross the bottom line of the stage. When players clear viruses, their attack meter fills; when the attack meter is full, players can send a row of viruses to their opponent. The number of viruses is dependent on the doctor's attack power; the higher their attack is, the more viruses they can send, but their attack meter fills more slowly than weaker doctors. Players can view their opponent's grid, as well as a dotted line indicator showing how far viruses are down on their opponent's stage. Additionally, players have a chance to prevent opponents from sending viruses to them; the higher their doctor's defense stat is, the likelier the attack will be defended against.

Players are sorted into tiers, which serves as the game's matchmaking feature. Players earn battle points if they win matches and lose battle points if they do not. When enough battle points are earned, players ascend tiers and the higher their tier is, the better rewards they earn for winning. Players earn keys for a battle box if they win battles, and if they have enough keys, they can open battle boxes to obtain random loot in them such as coins, hearts, tickets for assistance, etc., including two special assistants exclusive to higher tier battle boxes. Battle boxes can be open once every 10 hours after they have been opened.

Once every two to three months, the game is updated to add a new season, which adds new tiers.

Daily Booster
The Daily Booster, introduced in the version 1.3 update, replaces the Daily Gift. The player eliminates viruses to earn coins and doc tokens. Once all of them have been eliminated, everything on the stage is eliminated, and new viruses appear after a few seconds. If an object touches the bottom line, the game ends. The player gets four coins for every virus eliminated, and one doc token for every 45 viruses eliminated. It can be played for free once per day, and can be played again using diamonds, with the rewards being received at a tripled rate: each virus rewards twelve coins and each doc token is rewarded for every 15 viruses eliminated. Once a triple-reward game is finished, the player must wait until the next day to play this mode again.

Prior to version 1.3.5, a single music theme plays during both the Daily Booster rounds and the results screen. After that update, the theme that plays during the round has changed, with its old theme only played at the results screen.

Clinic Event
For this event, the player needs to do the following steps for the event:  
 * 1) Examine the patient.
 * 2) Eliminate the viruses.
 * 3) Clear all stages with three stars!

Once a step is cleared, the player earns rewards as well as a medal with the patient on it. The character depends on the current season:
 * Season 1: Blue Toad
 * Season 2: Goomba
 * Season 3: Spike
 * Season 4: Koopa Troopa
 * Season 5: Piranha Plant
 * Season 6: Green Toad
 * Season 7: Paragoomba
 * Season 8: Koopa Paratroopa
 * Season 9: Shy Guy
 * Season 10: Blooper

Collect Clear Stars
In Collect Clear Stars!, the player needs to collect stars and receive rewards. However, they do not count if they were previously earned.

Eliminate the viruses!
In Eliminate the viruses!, the player eliminates viruses in stages and receive rewards. They only count in stage mode.

Doctors
So far, Dr. Mario World features 36 playable characters. Each playable character offers a unique special skill that can be activated during gameplay. Players start with Dr. Mario when they first play the game and unlock Dr. Bowser and Dr. Peach when they reach Stage 11; if players pick one of the three characters, the other two characters become unavailable. Players can purchase new doctors with coins and diamonds in the Staffing menu of the game, although the doctors are obtained randomly and duplicates can occur. If players receive duplicate characters, it goes towards that doctor's skill level and players stop earning duplicates if a particular character has a maxed out skill level. Reaching new skill levels will also make the skill meter fill faster for that doctor in stage mode.

More doctors are planned to be added via software updates.

Doctor stats
The following are the stats for all doctors in Versus mode. The bomb displays how many rows of viruses the doctors can send to their opponents, the speed lists how many viruses or capsules are required to be eliminated for the meter to fill, and the defense represents the chance a doctor has to block against the bomb displayed. The rate skill meters are charged are hidden and differ from each doctor.

Assistants
So far, Dr. Mario World features 58 assistants. Assistants, like the doctors, have unique skills that aid the player. Up to two assistants can be selected at once. Like doctors, these characters' skills level up with play or by obtaining duplicates from the Staffing menu. Goomba is earned as the first assistant when players reach Stage 20.

More assistants are planned to be added via software updates.

Viruses
While the red, blue, and yellow viruses return from previous Dr. Mario titles, Dr. Mario World introduces four more colors of viruses: green, light-blue, purple, and pink.

Other characters

 * Dorrie
 * Toads
 * Stone-Eyes
 * Ice Bros
 * Bone Goombas
 * Lava Bubbles
 * Whomp
 * Foos

Worlds
There are five worlds total in the base game for Dr. Mario World. Each world is sorted into two areas, with each area containing 20 stages. Each world additionally contains three challenge levels which reward players with coins upon completion. New worlds are planned to be added in an update. When the player clears the first area of a world, they earn a coin or assistant reward. When a player clears the second area of a world, represented by a Goal Pole, they earn a staff ticket for use in the Staffing menu that can unlock new doctors or assistants, as well as a silver medal. If they earn all stars in a world, they earn a gold medal for that world; and clearing a special stage in a world rewards a platinum medal, 1000 coins and a doctor. In every special stage, there are blue, yellow, and pink viruses, except in World 13, where the red virus replaces the pink one. Several of the worlds' designs take some inspiration from the New Super Mario Bros. series.

More worlds are planned to be added in future updates.

Virus Vid


To promote Dr. Mario World, Nintendo released a series of short videos on social media featuring the viruses performing various activities, beginning on June 18, 2019 and ending on July 10, 2019, on a daily basis.

Animal Crossing: Pocket Camp
To celebrate the release of Dr. Mario World, three T-shirts based on the blue, red, and yellow viruses were made available to players for free in Animal Crossing: Pocket Camp on July 19, 2019.

Updates
The following is a list of updates the game has received since launch. The updates also has specific changes, via the in-game notifications.

Ver. 1.0.2
Release date: July 10, 2019


 * Implemented bug fixes.

Ver. 1.0.3
Release date: July 13, 2019


 * Implemented bug fixes.
 * We have included balance adjustments.

Ver. 1.0.4
Release date: August 5, 2019


 * Implemented bug fixes.
 * We have included balance adjustments.
 * Implemented feature improvements.

 This update provides the following bug fixes: 
 * Specific changes
 * Players become unable to proceed after clearing a stage.
 * In versus mode, an invisible wall appears in a completely empty area.

Ver. 1.0.5
Release date: August 7, 2019


 * Implemented bug fixes.

 This update fixes the following issues: 
 * Specific changes
 * When letting go of a capsule, it sometimes slips out of place.
 * When starting the game, sometimes save data cannot be loaded properly, and player temporarily cannot continue their game.

Ver. 1.1.0
Release date: September 30, 2019


 * ''Increased the number of times you can continue in stage mode to two.
 * It is now possible to accept a reward for linking your Nintendo Account and social media accounts.
 * Doctor's Orders difficulty and wait times have been reduced.
 * It is now possible to view the details for characters you do not have.
 * It is now possible to see your opponent's character information in versus mode.
 * General improvements to enhance the user's experience.

 
 * Specific changes
 * The character screen will offer more detailed information on how doctors perform in versus mode
 * You will be able to check details for characters you have yet to obtain
 * You will be able to check details for your opponent’s characters in versus mode
 * The number of times you can continue after running out of capsules in stage mode will be increased to two
 * The level-up animation for characters will change
 * You will be able to claim rewards after linking your Nintendo Account or social media accounts
 * The difficulty level for some doctor’s orders will be reduced. The wait time for doctor’s orders will also be reduced:
 * When orders are removed: 8 hours become 1 hour
 * When orders are completed: 20 hours become 6 hours
 * A Season system will be implemented for versus mode. Along with this change, battle points will be capped at 2000 when the season changes. However, when a new season begins, you will receive a bonus if you have earned more than 2000 points in the prior season
 * In “Find all the hidden coins!” stages, you will be able to acquire coins even if capsules cover them
 * You will be able to earn three clear stars when you complete a special stages
 * A red notification badge will appear on the Staffing icon when you have saved enough coins to add staff.


 * Unlisted changes
 * New results music is added when winning a match in versus mode, while the old results music prior to this version is used when losing a match.

Ver. 1.1.1
Release date: October 3, 2019


 * Unlisted changes
 * Implemented bug fixes.

Ver. 1.1.2
Release date: October 28, 2019


 * General improvements to enhance the user's experience.

Ver. 1.2.0
Release date: December 12, 2019


 * It is now possible to earn doctors by completing special stages.
 * Implemented doc tokens, which can be used in doc staffing.
 * Adjusted stage difficulty and the number of times items can be used.
 * Fixed bugs and made feature improvements.

 
 * Specific changes
 * It is now possible to earn doctors by completing special stages.
 * World 1: Dr. Toad
 * World 2: Dr. Yoshi
 * World 3: Dr. Bowser Jr.
 * World 4: Dr. Luigi
 * World 5: Dr. Toadette
 * World 6: Dr. Waluigi
 * World 7: Dr. Baby Luigi
 * World 8: Dr. Luma
 * World 9: Dr. Diddy Kong
 * Implemented doc tokens, which can be used in doc staffing. Collect 100 of them, and you can access the doc staffing option, where only doctors appear.
 * Adjusted stage difficulty and the number of times items can be used.
 * More Rewards for Challenge Stages: clear rewards have been added for Challenge Stages A and B in each world, and the rewards for Stage C have been increased.
 * Log-in Bonuses: a Log-in Bonus feature has been added.
 * Character Skill Adjustments: some assistant skills have been adjusted in versus mode.
 * We have adjusted the special bonus that is sometimes granted when a player fails the same stage multiple times in a row.
 * The restriction preventing players from using an item multiple times during stage mode has been removed.
 * The effect for the Time Boost item has been changed from “Adds 10 seconds to the clock!” to “Adds 15 seconds to the clock!”
 * In versus mode, players can now use diamonds to reduce the wait time for battle boxes.
 * The number of characters appearing in Staffing has changed:
 * Doctors: 20
 * Assistants: 40
 * The timing for when the number of coins you can obtain as a victory rewards in versus mode resets will be changed.
 * Fixed bugs and made feature improvements.


 * Unlisted changes
 * The menu buttons in stage mode and versus mode are adjusted.

Ver. 1.2.1
Release date: December 16, 2019


 * Unlisted changes
 * Implemented bug fixes.

Ver. 1.2.2
Release date: January 7, 2020


 * General improvements to enhance the user's experience.

Ver. 1.2.5
Release date: January 30, 2020


 * General improvements to enhance the user's experience.

Ver. 1.3.0
Release date: March 5, 2020


 * Added a Daily Booster stage that can be played every day.
 * Added a useful stage mode item, the boomerang.
 * Adjusted the number of diamonds required for some items.
 * Fixed bugs.
 * Made other minor adjustments.

 
 * Specific changes
 * To replace the Daily Gift, we will add a special stage where you can earn coins and doc tokens every day.
 * We will add a new item that can be used in stage mode. Along with this addition, we will also adjust the number of diamonds required for some existing items.
 * We will change the lineup under Special Packs in the shop.
 * New Packs: Boomerang Pack, Infinite Player Heart Pack
 * Removed Packs: Special Pack A and B

Ver. 1.3.1
Release date: March 9, 2020


 * Fixed bugs.


 * Specific changes
 * Fixed issue with inverted sound options in Settings.

Ver. 1.3.5
Release date: April 23, 2020


 * General improvements to enhance the user’s experience.
 * The game will reconnect if wireless communication becomes unstable during a versus mode match, as long as the outcome of the match has not yet been determined.


 * Unlisted changes
 * Balance adjustments impacting certain character skills were made.
 * Balance adjustments impacting gameplay in stage mode were made.
 * The music used for the Daily Booster mode is rearranged, while the music prior to this version is used exclusively for that mode's results screen.
 * The player icon in the stage map animates.

Ver. 1.4.0
Release date: June 26, 2020


 * Added new handy items: Capsule Swapper and Rainbow Start.
 * Note: Alongside these additions, removed the Capsule Blaster.
 * A Weekly Specialists feature has been added to versus mode.
 * Each week, some doctors will be chosen as specialists!
 * Balance adjustments made to the Daily Booster and the skills of some doctors.

 
 * Specific changes
 * The amount of information you can check on the screen before you start playing in stage mode has been increased.
 * Difficulty: This will display on difficult stages.
 * Objects: The main objects placed in the stage will be displayed.
 * Clear conditions: The conditions for clearing the stage will be displayed.
 * Best doctors: Doctors who are advantageous when playing the stage will be displayed.
 * In versus mode, your defence against your opponent's attacks will now be displayed.
 * Balance adjustments were made for certain doctors so that their stage mode skill meters fill faster.
 * Balance adjustments for certain doctors' skills were made.
 * We added the following new option for continues in stage mode.
 * Use 15 diamonds to add 5 rainbow capsules and resume playing.
 * You can now add friends when you finish a match in versus mode.
 * Certain other features have been improved.


 * Unlisted changes
 * On the stage clear screen, the player can tap the skip button to proceed through the animations faster.
 * The player can bypass to the staffing menu from the shop and character select menus.

Critical reception
At launch, Dr. Mario World received generally mixed to somewhat negative reviews. Critics were somewhat divided but leaned positively on its puzzle aspect and its multiplayer mode, but near unanimously criticized its overabundance of microtransactions and its online requirement. It currently holds a score of 58 on Metacritic based on sixteen reviews and a score of 55.94% on GameRankings based on eight reviews.

Chris Carter of Destructoid gave the game a 6/10, praising the accessibility and puzzles the game has to offer, but criticized the microtransactions, claiming "I've been playing mobile games consistently since Flight Control in 2009; so you could say I've had many encounters with energy systems and the like. The situation is definitely case-by-case, nuanced, and depending on the game the juice can absolutely be worth the squeeze. But seeing cute Mario characters reduced to this, with all of the psychological tricks in the book thrown in, is depressing. Just energy, just "you can finish this hard level if you pay," or just gacha would have been a lot as it is." In a review without a score, Ben Bertoli of IGN expressed skepticism over the change in gameplay compared to previous entries in the series, and was slightly more critical of the microtransactions, stating "While it doesn't make it unplayable, to be sure, it makes it very clear from the get-go where this Dr. Mario's priorities lie." He concluded that it was still a fairly decent game to play for those who enjoy puzzle games. In an even more negative review, Glen Fox of Gamezebo gave the game a 2/5, criticizing practically everything about the game; he called the puzzles "artificial difficulty" and "uninspired," and raised a larger furor over the microtransactions, stating that he never expected Nintendo to engage in such predatory practices.

In stark contrast to other critics, Chris Scullion of Nintendo Life gave the game an 8/10, and praised mainly the multiplayer mode. While he agreed with other critics that the single-player mode was muddled with excessive microtransactions, he believed that the gameplay was fitting for a mobile device, and believed the multiplayer mode would be the game's highlight.

On the Google Play storefront, Dr. Mario World currently has an average user score of 3.9 out of 5, while on Apple's App Store, it has an average user score of a 4.5 out of 5.

Sales
Dr. Mario World has received 2 million downloads in the first 72 hours of its launch. It additionally received $100,000 from its in-app purchases. While it had only half of the downloads Super Mario Run had in the same time window, which was exclusive only to iOS at launch, and it is the lowest grossing Nintendo mobile game at this launch window, Dr. Mario Worlds revenue is comparable to other games in its genre such as Candy Crush Friends Saga; Dr. Mario World generated 75% of the revenue compared to Candy Crush Friends Sagas $137,000 in the same markets.

Dr. Mario World has reached 5 million downloads globally and players have spent $500,000 on in-app purchases in its first week, which is comparable to the top 25 puzzle games in Dr. Mario World's genre; Toon Blast from Peak Games, for example, grossed approximately $325 million in 2018, yet saw just $90,000 in its first week. Dr. Mario World charted as the #1 free iPhone app in Japan and #6 in the US.

App Store description
 ■ Use your puzzle skills to eliminate pesky viruses!


 * Match capsules with viruses and watch them disappear! Simply match three objects of the same color vertically or horizontally to clear them.
 * Luckily, Dr. Mario and friends have virus-busting skills, and you can use leftover half-capsules to strategically zero in on especially meddlesome viruses.
 * Take your time, because each puzzling configuration of viruses must be cleared using a limited number of capsules. Keep calm to plan your approach, and you'll rid Dr. Mario's world of viruses in no time!

■ Paging Dr. Mario!


 * A colorful cast of viruses has Dr. Mario's world in a panic! Dr. Mario and friends have put on lab coats and grabbed capsules! Now they're ready to eliminate those unruly viruses.
 * Dr. Mario isn't the only one on call—Dr. Peach, Dr. Bowser, and others are on duty. Staff up with assistants like Goomba, Koopa Troopa, and Buzzy Beetle to help your doctors out with additional skills.
 * Doctors and assistants have various virus-busting skills, so experiment to find a combination that suits your style and pace.
 * Hundreds of stages over many different worlds are ready for you to save! New worlds, new doctors, and more will be delivered on a regular basis.

■ Play together with friends and family around the world!


 * You're not in this alone—send and receive stamina-giving hearts to use in stage mode! Then, show off your puzzle-solving progress.
 * In versus mode, you can turn up the intensity on your virus-busting by challenging others to a one-on-one showdown—without using hearts!
 * Find the right combo of doctor and assistants and aim for victory online to earn battle points and increase your tier!

Notes: 
 * This game is free to start, with optional in-game purchases.
 * Persistent Internet and compatible smart device required. Data charges may apply.
 * May contain advertising.
 * For information about our ads, please see the “How we use your information” section of the Nintendo Privacy Policy.

Bowser

 * "My minions! Grrr... I'll take care of all these viruses!"

Dr. Toad

 * "Oh no! Viruses have gotten everywhere! We'd better do something."
 * "Let's eliminate the viruses!"
 * "To eliminate a virus, you need to use a blue."
 * "I'll show you how to do it!"
 * "While holding the capsule, drag it onto the stage. If you let go, it will begin to rise toward the top of the screen."
 * "If the capsule collides with a virus or another object, it will stop moving."
 * "Once it stops moving, if blue colors match blue or blue, the virus will be eliminated!"
 * "Tap a capsule to rotate it."
 * "It can be helpful to rotate the capsule before moving it into the stage, too!"
 * "Tap, hold, and drag the capsule to move it."
 * "You can't move a capsule back toward the bottom of the screen, so be careful!"
 * "OK! We eliminated all the viruses. Go, us!"
 * "You have a blue of capsules. The number in the top right of the screen shows how many are left."
 * "Eliminate all the viruses before you run out of capsules to clear the stage!"
 * "If you run out of capsules... Well... Too bad. You'll have to try again!"
 * "You'd better pay attention to how many capsules you have left!"
 * "Look at that! Your next capsule has turned into a blue!"
 * "Rainbow capsules are special. They can match with objects of any color."
 * "After you make seven matches that eliminate viruses or capsules, one will appear."
 * "There's a blue on both the left and right sides of the stage that shows how many matches you've made."
 * "Use the rainbow capsule to eliminate a virus of any color!"
 * "You can use items now!"
 * "Tap an item to see what it does."
 * "If you select an item before starting a stage, it will be used when the stage begins."
 * "To use an item, you usually need diamonds or coins. But this time, I gave you an item for free. Give it a try!"
 * "That filled up your skill meter. Let's go ahead and use it!"
 * "Tap the skill button!"
 * "You now have access to all the items. I hope they'll help in your virus hunt!"
 * "Now that all the viruses are gone, our friends are back!"
 * "But wait! I see more viruses causing mischief up ahead. We've got to keep going!"
 * "And now the virus hunt begins!"
 * "Please select the doctor you want from among these three choices."
 * "This item, the blue, will charge up your blue."
 * "Let's try it out. First, match three pieces of the same color."
 * "Look at that! You've still got half a capsule there."
 * "You can tap and hold it to move it around, just like a full-sized capsule."
 * "Put half-capsules in empty spaces. You want to make the best use of your capsules that you can!"
 * "Now you can use the blue! This'll let you clear out all the capsules on the stage at once." (removed in version 1.4.0)
 * "You can now use the blue! Use it to change the color of your next capsule." (since version 1.4.0)
 * "You can now use the blue! It'll fill your doctor's skill meter in an instant."
 * "You can now use the blue! Select a row and you can clear it immediately." (since version 1.3.0)
 * "Here, take this one. Come on, give it a try!"
 * "You've entered a new area!"
 * "From here on, we'll need the help of blue characters."
 * "To add your new recruit to the team, tap the blue button."
 * "Characters are divided into two categories: blue and blue."
 * "Your doctor is your main character. You can choose one-and only one-at a time!"
 * "Each doctor has their own unique blue."
 * "Assistants? Well, they help doctors, of course. You can select two."
 * "The assistants you choose have blue that aid the doctor in the fight against viruses."
 * "Want to know what effect an assistant will have? Just tap the assistant to see."
 * "Now it's your turn. Choose an assistant."
 * "You've made your team! Let's try clearing a stage now."
 * "blue, the blue menu, and other features are now unlocked!"
 * "Welcome to versus mode! Here, you can compete with people from around the world in real-time, online battles."
 * "Depending on the outcome of these matches...you'll gain or lose battle points."
 * "As your battle points go up, you'll rise in tier, and be able to earn bigger rewards!"
 * "Let's head on over to versus mode and give it a try!"
 * "You battle by sending viruses to your opponent. But watch out! They can send viruses your way, too."
 * "If the stage fills with enough viruses that they cross the bottom line, you'll blue the match."
 * "Your blue will fill as you eliminate viruses."
 * "Your attack meter is full! When that happens, you'll attack your opponent with viruses."
 * "Look at that! Your attack was a success. Your opponent's stage got hit with a new row of viruses!"
 * "How many rows you send depends on your doctor's blue."
 * "The higher it is, the stronger the attack-but the longer it takes to charge up!"
 * "Different doctors fill up their attack meters at different rates. Try out some doctors, and find the one that you like!"
 * "Check out the map at the top right. It shows your opponent's stage."
 * "This dotted line shows how far down the viruses have gotten on your opponent's stage."
 * "Keep an eye on how your opponent is doing...and send over viruses at just the right time!"
 * "Be careful! Your opponent's attack meter is full!"
 * "What-? How did you DO that? You defended against their attack!"
 * "Oh, right! I forgot. You have a chance to defend against any attack."
 * "The higher your doctor's blue, the better chance you have to defend!"
 * "Your blue is full! Let's try using a skill."
 * "Each doctor has a skill of their own. There are lots of different ones!"
 * "Well, that should do you. You're ready to try out what you've learned on a real opponent!"
 * "How's the virus hunt going? I'd like to show you a little technique that might just help..."
 * "Get good at this, and you'll be eliminating viruses like a pro!"
 * "See how these viruses are surrounded by blocks?"
 * "If you tap and hold a capsule, you can drag it between the blocks!"
 * "See? No matter the obstacle, as long as there is space, you can put the capsule there."
 * "But be careful! If there's not enough space, you can't place a capsule!"
 * "Use this trick to your advantage and take care of those viruses!"
 * "Here's a little something to help you clear that tough stage!"
 * "Wow, somebody doesn't look so good... It's got to be those pesky viruses!"
 * "Give the patient an exam and see what you can do to make them feel better!"

Narrator

 * "Viruses have invaded-everywhere!"
 * "Both the Toads and Bowser's minions have been sent into a panic!"
 * "Hunt down all the viruses and save everyone!"
 * "The viruses must be stopped-THAT they can all agree on. Mario, Peach, and Bowser don their lab coats and head toward adventure! The virus hunt begins..."

Princess Peach

 * "The Toads are in danger... I have to help!"

Pre-release and unused content
Unused assets have been extracted from the game; this includes unused graphics for Dino Piranha, Cooligan, Ice Bro, Freezie, Bone Goomba, Lava Bubble, Urchin, Whomp and Whomp King assistants and unused text strings for Magikoopa and King Kaliente assistants. .

There are also medals featuring Boo indicating future Clinic Events, a golden ticket to unlock costumes for characters , medals themed to Super Mario Galaxy, and a black, spiky Fuzzy-looking creature wearing a surgical mask. .

References to other games

 * Super Mario series: This game's six worlds, as well as World 9, World 10 and World 11, are commonly featured across the Super Mario platformers.
 * Super Mario Bros.: The coin sound effect is directly taken from this game's NES version.
 * Dr. Mario: The music heard in the stage select and versus mode menu are the respective arrangements of the title screen from this game. The music heard in the staffing screen is an arrangement of the mode menu screen from this game.
 * Tetris & Dr. Mario: The music heard during Dr. Toad's first gameplay tutorial and Clinic Events is an arrangement of Music 1 from the Mixed Match mode from this game.
 * Super Mario Galaxy: A Star Bunny and Honey Queen appear as assistants. Dino Piranha's planet, the Starshroom, and the Comet Observatory appear on the World 8 map.
 * New Super Mario Bros. Wii: Dr. Wendy's artwork is based on Wendy's artwork from this game, albeit mirrored.
 * Donkey Kong Country Returns: One of Dr. Donkey Kong and Dr. Diddy Kong's artworks is based on Donkey and Diddy Kong's artwork from this game.
 * New Super Mario Bros. U: Dr. Ludwig's artwork is based on Ludwig's artwork from this game.
 * Mario Party 10: Most of the characters' victory, losing, and idle animations are taken from this game.
 * Super Mario Odyssey: Dr. Bowser's attire is similar to his normal self's wedding attire in this game.
 * Super Smash Bros. Ultimate: Dr. Roy's artwork is based on Roy's official render from this game.