Star Cure

The three Star Cures are the ultimate goal for much of the second half of Mario & Luigi: Bowser's Inside Story. Mario and Luigi first learn about the Star Cures from Doctor Toadley, shortly after a fight with Bowser.

Toadley tells the Bros. that the first vaccine is held by Durmite, who is usually located in Dimble Wood. However, the Marios had already found and beaten Durmite in Bowser's body. They discover that Durmite is still inside his body, and begin to pursue her. After a battle, Durmite, whose real name turns out to be Wisdurm, relinquishes the first Star Cure on friendly terms.

The second Star Cure, as it turns out, had come into Bowser's possession before the events of the game. He travels to a vault below his own castle to retrieve it. He is forced to do battle with the Fawful Express for the Star Cure. Mario and Luigi then need to reconstruct Bowser's damaged memory of the combination to the Star Cure's vault. When Bowser opens the vault, however, three traitorous minions, Private Goomp, Sergeant Guy, and Corporal Paraplonk, shove him inside. Starlow suggests that he swallow the Star Cure. He does so, and the Marios escape with it through a warp pipe.

The final Star Cure is held by Chakron, of Plack Beach. He gives it to the Marios after they successfully knock him out of his "1000 year pose" using Sweet Basket.

When all three Star Cures are brought back to Doctor Toadley, he combines them into the Miracle Cure, which cures every Toad that has contracted the Blorbs. It also breaks the barriers outside Peach's Castle, allowing the Marios to enter both the castle and the final stretch of the game.