Dr. Mario 64

Dr. Mario 64 is a puzzle game developed by Nintendo and released for the Nintendo 64. It was rereleased along with Tetris Attack and Yoshi's Cookie in a GameCube game called Nintendo Puzzle Collection in 2003, which was never released outside Japan.

Gameplay
Dr. Mario 64 plays the same as its predecessors for the most part. Dr. Mario throws Megavitamins into a jar full of Viruses, and lining up a combination of Viruses and Megavitamins (four at minimum), they disappear. There are three types of Viruses - the Red Virus (Fever), the Blue Virus (Chill) and the Yellow Virus (Weird), with a Megavitamin color designed to defeat them. Dr Mario 64 features many different modes of play. The first one is Classic mode, where you play Dr. Mario like it was originally. In the second mode of play, Story mode, Dr. Mario or Wario must track down the stolen Megavitamins. This mode only has versus matches against computers. The third mode allows practice against a computer player, where any character found in Story mode can be selected. The fourth game mode is Flash mode, where only the clearing of flashing Viruses counts. The fifth game mode is Marathon mode, which is basically an endless mode (the Viruses never stop coming out of the bottom of the jar). The sixth game mode is Score Attack mode, where there are only three minutes to get both a high score and clear all of the viruses. Multiplayer mode now supports up to four players, which adds a mode allowing four players to play on two teams.

Plot
Unlike past Dr. Mario games, this game has a plotline. The flu season has come about, and it's Dr. Mario's duty to use his Megavitamins to heal the people of the land. However, Wario, wanting to have the fame that Mario has, attempts to steal the Megavitamins, but to no avail. Afterwards, an old man named Mad Dr. Scienstein steals the Megavitamins, and both Dr. Mario and Wario go after him. Throughout their adventure, both of them meet up with many creatures, most of them being villains from the Wario Land video game series. Mad Dr. Scienstein was sent to steal the Megavitamins by a creature with a large, red nose: Rudy the Clown.