Star Cure

The three Star Vaccines are the ultimate goal for much of the second half of Mario & Luigi: Bowser's Inside Story. Mario and Luigi first learn about the Star Vaccines from Doctor Toadley, shortly after a fight with Bowser.

Toadley tells the Bros. that the first vaccine is held by Durmite, who is at Dimble Wood. However, the Marios have already found and beaten Durmite. Later, they discover that Durmite is still inside Bowser's Body, and begin to pursue her. After a battle, Durmite relinquishes the first Star Vaccine on friendly terms.

The second star vaccine, as it turns out, had come into Bowser's possession before the events of the game. He travels to a vault below his own castle to retrieve it. He is forced to do battle with the Fawful Express for the star vaccine. Mario and Luigi then need to reconstruct Bowser's damaged memory of the combination to the Star Vaccine's vault. When Bowser opens the vault, however, three traitorous minions, Private Goomp, Sergeant Guy, and Corporal Paraplonk, shove him inside. Starlow suggests that he swallow the Star Vaccine. He does so, and the Marios escape with it through a warp pipe.

The final star vaccine is held by Chakron, of Plack Beach. He gives it to the Marios after they successfully knock him out of his "1000 year pose" using Sweet Basket.

When all three Star Vaccines are brought back to Doctor Toadley, he combines them into the Miracle Cure, which cures every Toad that has contracted the Blorbs. It also breaks the barriers outside Peach's Castle, allowing the Marios to enter both the castle and the final stretch of the game.