Dr. Mario 64

Dr. Mario 64 is a puzzle game developed by Nintendo and is the final game released for the Nintendo 64. It was rereleased along with Tetris Attack and Yoshi's Cookie in a GameCube game called Nintendo Puzzle Collection in 2003, which was only released in Japan.

Gameplay
Dr. Mario 64 plays the same as its pre­de­cess­ors for the most part. Dr. Mario throws Mega&shy;vita&shy;mins into a jar full of Viruses, and the goal is to line up a minimum of four of a color combination of Viruses and Megavitamins to make them disappear. There are three types of Viruses - the Red Virus (Fever), the Blue Virus (Chill) and the Yellow Virus (Weird), with a Megavitamin color designed to defeat them.

Dr Mario 64 features many different modes of play. The player uses the D-Pad to toggle with the different modes they wish to select. The first one is Classic mode, where Dr. Mario is playable like he was originally. In the second mode of play, Story mode, Dr. Mario or Wario must track down the stolen Megavitamins. This mode only has versus matches against computers. The third mode allows practice against a computer player, where any character found in Story mode can be selected. The fourth game mode is Flash mode, where only the clearing of flashing Viruses counts. The fifth game mode is Marathon mode, which is basically an endless mode (the Viruses never stop coming out of the bottom of the jar). The sixth game mode is Score Attack mode, where there are only three minutes to get both a high score and clear all of the viruses. Multiplayer mode supports up to four players, which adds a mode allowing four players to play on two teams.

Plot
Unlike past Dr. Mario games, this game has a plotline. It's flu season, and it's Dr. Mario's duty to use his Megavitamins to heal the infirmities of the citizens of the land. However, Wario attempts to steal the Megavitamins. He believes that if he has them, he will be rich. Before he can do so, Mad Scienstein steals the Megavitamins. Dr. Mario runs into Wario, believing he has the Megavitamins, and they duel. Afterwards, they both go after Mad Scienstein. Throughout their adventure, both of them meet up with many creatures, all of them being villains taken from Wario Land 3. In the end, it is revealed Mad Scienstein stole the Megavitamins for the diabolical Rudy the Clown, who wishes to cure his cold. Dr. Mario defeats Rudy, takes back his trusty Megavitamins, and makes Rudy happy by curing his cold.

Wario's Story
Wario's story is slightly different in that his story features enemies that Dr. Mario doesn't face. In his ending he defeats Rudy but then Dr. Mario comes and tries to get the Megavitamins back. Wario rushes away, but he trips, making some Megavitamins falling out. Dr. Mario swallows all of them and transforms into Metal Mario. After Wario beats him, Mad Scienstein comes and runs off with the Megavitamins. Wario chases after him and the chase keeps on going forever.

Playable Characters

 * Dr. Mario
 * Wario
 * Spearhead
 * Webber
 * Silky
 * Appleby
 * Jellybob
 * Octo
 * Helio
 * Lumpy
 * Hammer-Bot
 * Mad Scienstein
 * Rudy the Clown
 * Metal Mario (unlockable)
 * Vampire Wario (unlockable)

References to Other Games

 *  Dr. Mario - The basic formula for the Dr. Mario series is carried on from this game.
 * Super Mario 64 - Metal Mario (as both a powered-up form of Dr. Mario and a secret unlockable character) is a power-up from this game.
 * Wario Land 3 - All characters apart from Dr. Mario and Metal Mario are from this game.